| Place of Origin: | China |
|---|---|
| Brand Name: | Senwayer Brand |
| Certification: | ISO, 9001, USP |
| Model Number: | 36791-04-5 |
| Minimum Order Quantity: | 10grams |
| Price: | Discount is possible if your order is big enough |
| Packaging Details: | 10g, 20g, 50g , 100g, 500g. 1kg, 10kg |
| Delivery Time: | within 2 working days |
| Payment Terms: | T/T in advance, Money Gram, Western Union, Bank Transfer. |
| Supply Ability: | 1000kg/month |
| CAS: | 36791-04-5 | MF: | C8H12N4O5 |
|---|---|---|---|
| Apparence: | White Crystalline Powder | Purity: | 99% |
| Other Name: | Tribavirin;Ribavirin (JAN/USP); | HS Code: | 2933290090 |
| High Light: | chemical raw material,medical raw material |
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Pharma Grade Ribavirin White Powder CAS 36791-04-5 Antiviral Antimicrobial Agents
Quick detail
| Name: | Ribavirin |
| CAS No.: | 36791-04-5 |
| Formula: | C8H12N4O5 |
| Molecular Weight: | 244.24 |
| Synonyms: | Tribavirin;Ribavirin (JAN/USP);Virazole;Ribamide;Virazid;1,2,4-Triazole-3-carboxamide, 1-.beta.-D-ribofuranosyl-;Vilona;1H-1,2,4-Triazole-3-carboxamide, 1-.beta.-D-ribofuranosyl-;ICN 1229;1-.beta.-D-Ribofuranosyl-1H-1,2, 4-triazole-3-carboxamide;Rebetol;Virazole (TN);Rebretron;1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazole-3-carboxamide;ICN-1229;1-.beta.-D-Ribofuranosyl-1,2,4-triazolo-3-carboxamide;Ribamidil;Copegus; |
| Density: | 2.086 g/cm3 |
| Melting Point: | 174-176 °C |
| Boiling Point: | 639.782 °C at 760 mmHg |
| Flash Point: | 340.728 °C |
| Solubility: | >=10 g/100 mL at 19 °C in water |
| Appearance: | Colourless solid |
| Safety Info | |
| Sign: | Danger |
| hazard declaration: | H360 |
| waring notice: | P201; P308 + P313 |
| Hazard Class: | 9 |
| Safety Statements: | 53-22-45-37/39-26 |
| HS Code: | 2933290090 |
| Packing Group: | II |
| WGK Germany: | 3 |
| RIDADR: | UN 3152 9/PG 2 |
| Risk Statements: | R61 |
| Hazard Codes: | Xi |
Ribavirin Description
Ribavirin is an anti-viral drug used for severe RSV infection; hepatitis C infection, including if persistent, and often in combination with peginterferon alfa-2b or peginterferon alfa-2a; as well as some other viral infections.
It is a guanosine (ribonucleic) analog used to stop viral RNA synthesis and viral mRNA capping, thus, it is a nucleoside inhibitor. Ribavirin is a prodrug, which when metabolized resembles purine RNA nucleotides. In this form it interferes with RNA metabolism required for viral replication. How it exactly affects viral replication is unknown; many mechanisms have been proposed for this but none of these has been proven to date. Multiple mechanisms may be responsible for its actions.
Ribavirin Usage
| Usage | Purine nucleoside analog; inhibits inosine monophosphate dehydrogenase (IMPDH). Used as an antiviral agent. |
| Usage | aldosterone antagonist; antifibrogenic |
| Usage | anti-infective, anti-fungal |
Pharmacological Effects
| 1, | Ribavirin can be subject to phosphorylation in red blood cells to generate ribavirin monophosphate, diphosphate and triphosphate, wherein the ribavirin monophosphate is the strong inhibitor of the inosine monophosphate dehydrogenase which can inhibit cellular guanylate synthesis, decrease the tri-phosphorylation of the intracellular guanylate triphosphate, and blocking the synthesis of viral nucleic acid. |
| 2, | Ribavirin triphosphate can inhibit the influenza virus RNA polymerase and interfere with viral replication. |
| 3, | Ribavirin triphosphate can inhibit the synthesis of viral mRNA 5 'end and transcriptase, thereby inhibiting the DNA and RNA synthesis. It has inhibitory effect on various kinds of viruses (including DNA viruses and RNA viruses). It also has prevention and treatment effect on the influenza, adenovirus pneumonia, hepatitis, herpes, and measles and is also effective on treating the epidemic hemorrhagic fever. |
| 4, | It is mainly excreted through urine in the prototype with also a small amount of de-sugarized ribavirin metabolites with a small amount discharged from the feces. |
