| Place of Origin: | China |
|---|---|
| Brand Name: | Senwayer Brand |
| Certification: | ISO, 9001, USP |
| Model Number: | 656247-17-5 |
| Minimum Order Quantity: | 10grams |
| Price: | Discount is possible if your order is big enough |
| Packaging Details: | 10g, 20g, 50g , 100g, 500g. 1kg, 10kg |
| Delivery Time: | within 2 working days |
| Payment Terms: | T/T in advance, Money Gram, Western Union, Bank Transfer. |
| Supply Ability: | 1000kg/month |
| CAS: | 656247-17-5 | Apparence: | White Powder |
|---|---|---|---|
| Purity: | 99% | Other Name: | Intedanib; Imidafenacin; Uritos; Staybla; |
| Usage: | Treatment Of Idiopathic Pulmonary Fibrosis (IPF) | Stock: | Available |
| High Light: | antineoplastic drugs,breast cancer drugs |
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Nintedanib CAS 656247-17-5 Treatment of Idiopathic Pulmonary Fibrosis (IPF) Powder
Quick detail
| Nintedanib | |
| CAS No.: |
656247-17-5 |
| Formula: | C31H33N5O4 |
| Exact Mass: | 539.25300 |
| Molecular Weight: | 539.62500 |
| PSA: | 94.22000 |
| LogP: | 3.70270 |
Nintedanib Description
Nintedanib, marketed under the brand names Ofev and Vargatef, is a medication used for the treatment of idiopathic pulmonary fibrosis (IPF) and along with other medications for some types of non-small-cell lung cancer.
Common side effects include abdominal pain, vomiting, and diarrhea. It is a small molecule tyrosine-kinase inhibitor, targeting vascular endothelial growth factor receptor (VEGFR), fibroblast growth factor receptor (FGFR) and platelet derived growth factor receptor (PDGFR).
How nintedanib Works
| How nintedanib Works | 1. Nintedanib inhibits tyrosine kinase, an enzyme essential for signal transduction pathways that trigger growth factors like vascular endothelial growth factor receptor (VEGFR), fibroblast growth factor receptor (FGFR), and platelet derived growth factor receptor (PDGFR), which are secreted in excess amounts in patients with IPF. 2. These growth factors promote collagen production and deposition and help in the differentiation, maturation, and proliferation of the fibroblasts, which eventually lead to the formation of scar tissues in the lungs. 3. Nintedanib binds to the phosphorylating site of tyrosine kinase, which blocks the cell signaling mechanism, slowing the progression of the disease. |
Nintedanib Sise Effect
| side effects |
The following side effects are associated with nintedanib:
|
Do NOT use nintedanib if
Contact your doctor or health care provider right away if any of these apply to you.
