CAS 1051375-16-6 Raw Material Drug Anti ADIS Dolutegravir Powder GSK1349572

Dolutegravir CAS 1051375-16-6 Anti-ADIS Raw Material Drugs GSK1349572 White Powder

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Dolutegravir Description

Dolutegravir is used with other medications to treat human immunodeficiency virus (HIV) infection in adults and children who are at least 12 years of age and weigh at least 88 lb (40 kg). Dolutegravir is in a class of medications called HIV integrase inhibitors. It works by decreasing the amount of HIV in your blood and increasing the number of immune cells that help fight infections in your body.

Although dolutegravir does not cure HIV, using it along with other medications may decrease your chance of developing acquired immunodeficiency syndrome (AIDS) and HIV-related illnesses such as serious infections or cancer. Taking these medications along with practicing safer sex and making other lifestyle changes may decrease the risk of transmitting (spreading) the HIV virus to other people.

Dolutegravir is a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector.

Side effects can dolutegravir cause

Dolutegravir may cause side effects. Most side effects from dolutegravir are manageable, but a few can be serious. Serious side effects of dolutegravir include allergic reactions and liver problems. (See the WARNING box above.)

Other possible side effects of dolutegravir include:

• Changes in liver test results. People with a history of HBV or HCV infection may have an increased risk of developing new or worsening changes in certain liver test results during treatment with dolutegravir.
• Changes in body fat (including gain or loss of fat).
• Immune reconstitution inflammatory syndrome (IRIS), a condition that sometimes occurs when the immune system begins to recover after treatment with an HIV medicine. As the immune system gets stronger, it may have an increased response to a previously hidden infection.
• Trouble sleeping, tiredness, and headache, which are among the most common side effects of dolutegravir.

Tell your health care provider if you have any side effect that bothers you or that does not go away.