| Place of Origin: | China |
|---|---|
| Brand Name: | Senwayer Brand |
| Certification: | ISO, 9001, USP |
| Model Number: | 104987-11-3 |
| Minimum Order Quantity: | 10grams |
| Price: | Discount is possible if your order is big enough |
| Packaging Details: | 10g, 20g, 50g , 100g, 500g. 1kg, 10kg |
| Delivery Time: | within 2 working days |
| Payment Terms: | T/T in advance, Money Gram, Western Union, Bank Transfer. |
| Supply Ability: | 1000kg/month |
| CAS: | 104987-11-3 | MF: | C44H69NO12 |
|---|---|---|---|
| Apparence: | White Crystalline Powder | Purity: | 99% |
| Grade: | Pharma Grade | Stock: | Enough Stock |
| High Light: | anti allergy medicine,anti histaminic drugs |
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Tacrolimus CAS 104987-11-3 Raw Material Drugs Treatment of Cushing's Syndrome Powder
Quick detail
| Name: | Tacrolimus |
| CAS No.: | 104987-11-3 |
| Formula: | C44H69NO12 |
| Molecular Weight: | 804.02 |
| Synonyms: | 4,5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-heptadecahydro-5,19-dihydroxy-3-;FK-506;FK506;FR 900506;Prograf;dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-,(3S,4R,5S,8R,12S,14S,15R,16S,18R,19R,26aS)-;FK 506;Fujimycin;FR-900506;[(E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-; Tacrolimus (FK506);Tacrolimus(FK-506);Tacrolimus(FK506);Tacrolimus, FK-506; Taccrolimus; Tacrolimus [GMP];15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(23H)-tetrone,;Prograde metamorphismPrograf; |
| Density: | 1.19 g/cm3 |
| Melting Point: | 113-115 °C |
| Boiling Point: | 871.7 °C at 760 mmHg |
| Flash Point: | 481 °C |
| Solubility: | DMSO: >3 mg/mL |
| Appearance: | White or off-white crystalline powder |
Tacrolimus Description
Tacrolimus ointment helps reduce inflammatory skin reactions. It is prescribed for people with moderate-to-severe eczema, usually as an alternative to other treatments such as steroid creams or ointments. It is applied topically (on to the skin) to reduce symptoms such as inflammation, redness and itching. Tacrolimus ointment is available in two strengths: 0.03% and 0.1%. Only the lower, 0.03% strength, is suitable for use by children. It will be prescribed initially by a skin specialist doctor.
Tacrolimus is also available as a medicine which is taken by mouth, but this is prescribed for a completely different medical condition. There is a separate information leaflet available about this called Tacrolimus to prevent organ rejection.
Tacrolimus Usage
| Usage 1 | An immunosuppressant that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 binding protein, thereby reversing its effects on sarcoplasmic reticulum Ca+2 release. |
| Usage 2 | FK-506 (Tacrolimus) is a macrolide immunosuppressive drug that is mainly used after allogeneic organ transplant to reduce the activity of the patient's immune system |
| Usage 3 | Tacrolimus (fujimycin) was discovered as a potent inhibitor of IL2 production in a targeted search for novel immunosuppressants. Tacrolimus acts by blocking T cell proliferation in vitro by inhibiting the generation of several lymphokines, notably the original target IL-2. Tacrolimus inhibits the activity of FK-506 binding protein, Ca2+-dependent phosphatase and calcineurin, and activates NF-κB through phosphorylation and degradation of IκBα. |
| Usage 4 | treatment of Cushing's syndrome |
| Usage 5 | For use after allogenic organ transplant to reduce the activity of the patient's immune system and so the risk of organ rejection. It was first approved by the FDA in 1994 for use in liver transplantation, this has been extended to include kidney, heart, |
How to use Tacrolimus
Tacrolimus Specification
| Tests | Specifications | Results |
| Description | A white or off-white crystalline powder | Conform |
| Identification | 1. IR (USP <197K>) | Conform |
| 2. HPLC retention times | Conform | |
| Water (USP <921> Method I) |
1.6 ~ 3.0% | 2.1% |
| Residue on ignition (USP <281>) |
£ 0.2% | 0.08% |
| Heavy metals (USP <231> II) |
£ 20 ppm | < 20 ppm |
| Related substances (In-house HPLC method) | Ascomycin £ 0.8% | 0.064% |
| Residual solvents (In-house method) |
Acetone £ 2000 ppm | Not detected |
| Assay (on anhydrous basis) | 98.0% ~ 102.0% | 99.8.0% |
| Conclusion: Complied with In-House standard | ||
