CAS 58-33-3 Promethazine Hydrochloride Drug For Antihistaminic Antiemetic

Basic Information
Place of Origin: China
Brand Name: Senwayer Brand
Certification: ISO, 9001, USP
Model Number: 58-33-3
Minimum Order Quantity: 10g
Price: Discount is possible if your order is big enough
Packaging Details: 10g, 20g, 50g , 100g, 500g. 1kg, 10kg
Delivery Time: within 2 working days
Payment Terms: T/T in advance, Money Gram, Western Union, Bank Transfer.
Supply Ability: 50KG / Month
Detail Information
CAS: 58-33-3 MF: C17H21ClN2S
Apparence: White Crystalline Powder Purity: 99%
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pharmaceutical raw material


chemical raw material

Product Description

Promethazine hydrochloride 58-33-3 Raw Material Drug For Antihistaminic Antiemetic

Quick detail

Product Name: Promethazine hydrochloride
Synonyms: 10-(2-dimethylamino-1-propyl)phenothiazine hydrochloride;PROMETHAZINE HCL;PROMETHAZINE HYDROCHLORIDE;PHENERGAN;10-(2-(dimethylamino)propyl)phenothiazinemonohydrochloride;10-(2-(dimethylamino)propyl)-phenothiazinmonohydrochloride;10-(2-dimethylaminopropyl)phenothiazinehydrochloride;10-(3-dimethylaminoisopropyl)phenothiazinehydrochloride
CAS: 58-33-3
MF: C17H21ClN2S
MW: 320.88
EINECS: 200-375-2
Product Categories: Active Pharmaceutical Ingredients;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;Histamine receptor;API;COLACE;Inhibitors
Melting point 230-232°C
storage temp. Refrigerator
Merck 13,7878


Promethazine is a neuroleptic medication and first-generation antihistamine of the phenothiazine family. The drug has strong sedative and weak antipsychotic effects. It also reduces motion sickness and has antiemetic and anticholinergic properties (via its action on the Dopamine receptor D2). In some countries it is prescribed for insomnia when benzodiazepines are contraindicated.



1 Promethazine hydrochloride is used to treat allergic conditions, travel sickness and sleeping difficulties.
2 It is used to treat allergic conditions, to prevent nausea and vomiting, and to aid relaxation and sleep.
3 It is a sedating antihistamine, sometimes known as a phenothiazine.
4 In general this drug is used to treat allergic conditions such as hay feverand urticaria and relieve nausea and vomiting due to travel sickness. Hay fever is a condition with inflammation of the nose arising from an allergy topollen. This leads to cold-like symptoms, such as sneezing, itchiness and a blocked or runny nose. Urticaria is a skin condition, often known ashives or nettle rash. The symptoms of urticaria include a red, itchy rash.
5 Benefits of being on this drug can include a reduction in symptoms associated with hay fever and urticaria in people with these allergic conditions. It also effectively controls symptoms of travel sickness but does cause sleepiness and drowsiness.


CAS 58-33-3 Promethazine Hydrochloride Drug For Antihistaminic Antiemetic 0


Reactivity Profile

Promethazine hydrochloride is sensitive to light. In aqueous solution, Promethazine hydrochloride is degraded by heat and light (more rapidly in air or oxygen). Incompatible with alkalis and alkaline solutions such as those of aminophylline, soluble barbiturates and phenytoin sodium. Iron(III) and copper(III) accelerate the degradation .



Test Items Specification Test Results
Description White crystalline powder White crystalline powder
Identification IR , UV conform Conform
Loss on drying ≤0.5ml 0.21ml
Residue on ignition Not more than 0.2% 0.06ml
Iron Not more than 0.005% 0.0018%
Heavy metals Not more than 0.001% 0.0006%
Related substances Total: Not more than 1.0%
Individual: Not more than 0.5%
E-isomer Not more than 0.3% 0.19%
Organic volatile impurities Conforms Conforms
Assay 99.0~101.0% 99.51%
Conclusion Conform with USP30

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