| Place of Origin: | China |
|---|---|
| Brand Name: | Senwayer Brand |
| Certification: | ISO, 9001, USP |
| Model Number: | 58-33-3 |
| Minimum Order Quantity: | 10g |
| Price: | Discount is possible if your order is big enough |
| Packaging Details: | 10g, 20g, 50g , 100g, 500g. 1kg, 10kg |
| Delivery Time: | within 2 working days |
| Payment Terms: | T/T in advance, Money Gram, Western Union, Bank Transfer. |
| Supply Ability: | 50KG / Month |
| CAS: | 58-33-3 | MF: | C17H21ClN2S |
|---|---|---|---|
| Apparence: | White Crystalline Powder | Purity: | 99% |
| High Light: | pharmaceutical raw material,chemical raw material |
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Promethazine hydrochloride 58-33-3 Raw Material Drug For Antihistaminic Antiemetic
Quick detail
| Product Name: | Promethazine hydrochloride | ||
| Synonyms: | 10-(2-dimethylamino-1-propyl)phenothiazine hydrochloride;PROMETHAZINE HCL;PROMETHAZINE HYDROCHLORIDE;PHENERGAN;10-(2-(dimethylamino)propyl)phenothiazinemonohydrochloride;10-(2-(dimethylamino)propyl)-phenothiazinmonohydrochloride;10-(2-dimethylaminopropyl)phenothiazinehydrochloride;10-(3-dimethylaminoisopropyl)phenothiazinehydrochloride | ||
| CAS: | 58-33-3 | ||
| MF: | C17H21ClN2S | ||
| MW: | 320.88 | ||
| EINECS: | 200-375-2 | ||
| Product Categories: | Active Pharmaceutical Ingredients;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;Histamine receptor;API;COLACE;Inhibitors | ||
| Melting point | 230-232°C | ||
| storage temp. | Refrigerator | ||
| Merck | 13,7878 | ||
Description
Promethazine is a neuroleptic medication and first-generation antihistamine of the phenothiazine family. The drug has strong sedative and weak antipsychotic effects. It also reduces motion sickness and has antiemetic and anticholinergic properties (via its action on the Dopamine receptor D2). In some countries it is prescribed for insomnia when benzodiazepines are contraindicated.
Usage
| 1 | Promethazine hydrochloride is used to treat allergic conditions, travel sickness and sleeping difficulties. |
| 2 | It is used to treat allergic conditions, to prevent nausea and vomiting, and to aid relaxation and sleep. |
| 3 | It is a sedating antihistamine, sometimes known as a phenothiazine. |
| 4 | In general this drug is used to treat allergic conditions such as hay feverand urticaria and relieve nausea and vomiting due to travel sickness. Hay fever is a condition with inflammation of the nose arising from an allergy topollen. This leads to cold-like symptoms, such as sneezing, itchiness and a blocked or runny nose. Urticaria is a skin condition, often known ashives or nettle rash. The symptoms of urticaria include a red, itchy rash. |
| 5 | Benefits of being on this drug can include a reduction in symptoms associated with hay fever and urticaria in people with these allergic conditions. It also effectively controls symptoms of travel sickness but does cause sleepiness and drowsiness. |
Reactivity Profile
Promethazine hydrochloride is sensitive to light. In aqueous solution, Promethazine hydrochloride is degraded by heat and light (more rapidly in air or oxygen). Incompatible with alkalis and alkaline solutions such as those of aminophylline, soluble barbiturates and phenytoin sodium. Iron(III) and copper(III) accelerate the degradation .
COA
| Test Items | Specification | Test Results |
| Description | White crystalline powder | White crystalline powder |
| Identification | IR , UV conform | Conform |
| Loss on drying | ≤0.5ml | 0.21ml |
| Residue on ignition | Not more than 0.2% | 0.06ml |
| Iron | Not more than 0.005% | 0.0018% |
| Heavy metals | Not more than 0.001% | 0.0006% |
| Related substances | Total: Not more than 1.0% Individual: Not more than 0.5% |
0.32% 0.14% |
| E-isomer | Not more than 0.3% | 0.19% |
| Organic volatile impurities | Conforms | Conforms |
| Assay | 99.0~101.0% | 99.51% |
| Conclusion | Conform with USP30 | |
