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Oral Active Pharmaceutical Ingredients Powder CAS 52-01-7 Spironolactone

Basic Information
Place of Origin: China
Brand Name: Senwayer Brand
Certification: ISO, 9001, USP
Model Number: 52-01-7
Minimum Order Quantity: 10grams
Price: Discount is possible if your order is big enough
Packaging Details: 10g, 20g, 50g , 100g, 500g. 1kg, 10kg
Delivery Time: within 2 working days
Payment Terms: T/T in advance, Money Gram, Western Union, Bank Transfer.
Supply Ability: 1000kg/month
Detail Information
CAS: 52-01-7 Apparence: White Powder
Purity: 99% Storage: Shading, Confined Preservation
Usage: Used As A Diuretic, Lactone (spironolactone), Stock: Enough Stock
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Product Description

Oral Active Pharmaceutical Ingredients Spironolactone 52-01-7 Used as a Diuretic

 

Quick detail


Name: Spironolactone
CAS No.: 52-01-7
Formula: C24H32O4S
Molecular Weight: 416.62
Density: 1.24 g/cm3
Melting Point: 207-208 °C(lit.)
Boiling Point: 597 °C at 760 mmHg
Flash Point: 302.3 °C
Solubility: practically insoluble in water
Appearance: White to Off White Solid

Used as a diuretic, lactone (spironolactone), the active metabolite. Inhibition of aldosterone biosynthesis. Wow effect of blockers for Pakistan It is a synthetic 17-lactone steroid which is a renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics, used primarily to treat ascites in patients with liver disease, low-renin hypertension, hypokalemia.

 

Spironolactone​ ​Description


Aldactone removes excess fluid from the body in congestive heart failure, cirrhosis of the liver, and kidney disease.


It also can be used in combination with other drugs to treat elevated blood pressure, and for treating diuretic-induced low potassium (hypokalemia).


Aldactone also is used to counteract the effects of excessive adrenal aldosterone production (hyperaldosteronism). Aldosterone overproduction can occur from a tumor in the adrenal gland or enlarged adrenal glands (hyperplasia of the adrenal glands).

 

Spironolactone Specification:


Ref. standard EP8/USP39
Analysis items Specification Results
Appearance white or yellowish-white powder White powder
Solubility Practically insoluble in water, soluble in ethanol(96 per cent). Complies
Identification A/B/C Meet the requirements Complies
Specific rotation

- 41 to -46°(EP) -41 to -45°(USP)

-43°
Loss on drying Not more than 0.5% 0.08%
Sulfated ash Not more than 0.1% 0.03%

Impurity A and Impurity C

Not more than 0.2%

N.D

Impurity F and Impurity E

Not more than 0.3% N.D
Impurity D Not more than 0.15% N.D
Impurity I Not more than 0.5% N.D
Other arbitrary unknown impurities Not more than 0.1% Complies
Total impurities Not more than 0.7% 0.15%
Ordinary impurities(USP) Not more than 2.0% 0.05%
Free thiol compounds(EP) Not more than 0.05 ml Complies
Free mercapto compounds(USP) Not more than 0.1ml Complies
Chromium(EP) 50ppmNot more than 50ppm Complies
Assay

97.0%~103.0%(USP) 97.5-102%(EP)

99.9% (USP) / 100.1% (EP)

Fineness 95% Not more than 20 μm Complies
Conclusion Qualified

 

Oral Active Pharmaceutical Ingredients Powder CAS 52-01-7 Spironolactone 0

 

Side Effects of Spironolactone


  1. Vomiting, diarrhea, and stomach pain or cramps
  2. Dry mouth and thirst
  3. Dizziness, unsteadiness, and headache
  4. Gynecomastia (enlarged breast tissue) in men, and breast pain in women
  5. Irregular menstrual periods and post-menopausal vaginal bleeding
  6. Erectile dysfunction
  7. Deepening of the voice and increased hair growth
  8. Drowsiness, tiredness, and restlessness

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  1. Rich experience in loading a great amount of containers in Chinese sea port;
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  5. Rich experience inKorea,India &Europe export;

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