|Place of Origin:||China|
|Brand Name:||Senwayer Brand|
|Certification:||ISO, 9001, USP|
|Minimum Order Quantity:||10grams|
|Price:||Discount is possible if your order is big enough|
|Packaging Details:||10g, 20g, 50g , 100g, 500g. 1kg, 10kg|
|Delivery Time:||within 2 working days|
|Payment Terms:||T/T in advance, Money Gram, Western Union, Bank Transfer.|
|Apparence:||Almost White Powder||Purity:||99%|
|Stock:||Enough Stock||Grade:||Pharma Grade|
anti inflammatory medications,
anti histaminic drugs
Medical Prostaglandin E2 Dinoprostone CAS 363-24-6 Anti-inflammatory Drugs Powder
|Synonyms:||5-Heptenoicacid, 7-[3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl]- (8CI);(-)-Prostaglandin E2;(15S)-Prostaglandin E2; Cervidil;Cerviprime;Dinoprostone;Enzaprost E;Minprositin E2;NSC 196514;PGE2;Primiprost;Prostaglandin E2;Prostenon;Prostenone;Prostin (prostaglandin);U 12062;l-Prostaglandin E2;|
|Melting Point:||66-68 °C|
|Boiling Point:||530.1 °C at 760 mmHg|
|Flash Point:||288.5 °C|
|Solubility:||ethanol: 1 mg/mL|
|Appearance:||white to pale yellowish-cream powder|
Prostaglandin E(2) (PGE(2)), a cyclooxygenase (COX) product, is the best known lipid mediator that contributes to inflammatory pain. Nonsteroidal anti-inflammatory drugs (NSAIDs), inhibitors of COX-1 and/or COX-2, suppress inflammatory pain by reducing generation of prostanoids, mainly PGE(2), while they exhibit gastrointestinal, renal and cardiovascular toxicities.
Selective inhibitors of microsomal PGE synthase-1 and subtype-selective antagonists of PGE(2) receptors, particularly EP(1) and EP(4), may be useful as analgesics with minimized side-effects. Protein kinase C (PKC) and PKA downstream of EP(1) and EP(4), respectively, sensitize/activate multiple molecules including transient receptor potential vanilloid-1 (TRPV1) channels, purinergic P2X3 receptors, and voltage-gated calcium or sodium channels in nociceptors, leading to hyperalgesia. PGE(2) is also implicated in neuropathic and visceral pain and in migraine.
Thus, PGE(2) has a great impact on pain signals, and pharmacological intervention in upstream and downstream signals of PGE(2) may serve as novel therapeutic strategies for the treatment of intractable pain.
The most common and most biologically potent of mammalian prostaglandins. Isolated from sheep prostate. Oxytocic; abortifacient.