| Place of Origin: | China |
|---|---|
| Brand Name: | Senwayer Brand |
| Certification: | ISO, 9001, USP |
| Model Number: | 50-23-7 |
| Minimum Order Quantity: | 10grams |
| Price: | Discount is possible if your order is big enough |
| Packaging Details: | 10g, 20g, 50g , 100g, 500g. 1kg, 10kg |
| Delivery Time: | within 2 working days |
| Payment Terms: | T/T in advance, Money Gram, Western Union, Bank Transfer. |
| Supply Ability: | 1000kg/month |
| CAS: | 50-23-7 | Alias: | Hydrocortisone , Beta-Hydrocortisone |
|---|---|---|---|
| Apparence: | Almost White Powder | Purity: | 99% |
| Usage: | For Ulcerative Colitis And Asthma Sepsis | Grade: | Pharma Grade |
| High Light: | anti inflammatory medications,anti histaminic drugs |
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Hydrocortisone CAS 50-23-7 Glucocorticoids For Ulcerative Colitis and Asthma Sepsis
Quick detail
Name: Hydrocortisone
CAS No.: 50-23-7
Formula: C21H30O5
Molecular Weight: 362.46
EINECS: 200-020-1
Density: 1.28 g/cm3
Melting Point 211-214 °C(lit.)
Boiling Point 566.4 °C at 760 mmHg
Flash Point: 310.4 °C
Solubility: water: 100 mg/mL
Appearance: crystalline white powder
Introduction of Hydrocortisone
Hydrocortisone is one kind of crystalline white powder.
The IUPAC Name of this chemical is (8S,9S,10R,11S,13S,14S,17R)-11,17-Dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one.
In addition, the Classification Code of this chemical is Anti-Inflammatory Agents; Drug / Therapeutic Agent; Glucocorticoid; Mutation data; Reproductive Effect. Hydrocortisone is very slightly soluble in water and sparingly soluble in alcohol.
Uses of Hydrocortisone
Hydrocortisone (CAS NO.50-23-7) is used to treat a variety of different illnesses. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.
Toxicity of Hydrocortisone
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect |
| man | TDLo | oral | 400mg/kg/10D- (400mg/kg) | BEHAVIORAL: CHANGES IN PSYCHOPHYSIOLOGICAL TESTS |
| mouse | LD50 | subcutaneous | > 500mg/kg (500mg/kg) | |
| rat | LD50 | intraperitoneal | 150mg/kg (150mg/kg) | |
| rat | LD50 | subcutaneous | 449mg/kg (449mg/kg) |
Hydrocortisone dosing information
Acute Adrenal Crisis:
100 mg IV followed by IV infusion of 200 mg over 24 hours OR 50 mg IV every 6 hours; then 100 mg IV the following day
Management of Primary Adrenal Insufficiency (PAI):
15 mg to 25 mg orally in 2 or 3 divided doses per day
-Highest dose should be given in the morning, then 2 hours after lunch (2-dose/day regimen) or at lunch and afternoon (3-dose/day regimen)
Prevention of Acute Adrenal Crisis:
Adjust dose according to severity of illness or magnitude of stressor
200 mg per day by continuous IV infusion
Recommendations from the International Guidelines for Management of Severe Sepsis and Septic Shock 2016:
-IV hydrocortisone should not be used if adequate fluid resuscitation and vasopressor therapy are able to restore hemodynamic stability
-Steroids should not be used in septic patients to prevent septic shock as there is a lack of evidence to support this
-Continuous infusion is recommended over repetitive bolus injections as repetitive boluses have been shown to significantly increase blood glucose
-Taper hydrocortisone treatment when vasopressors no longer required
Use: For the treatment of septic shock when adequate fluid resuscitation and vasopressor therapy are not able to restore hemodynamic stability.
100 mg IV every 8 hours during surgical period; dose should be rapidly reduced within 24 hours after surgery
Use: To reduce risks of complications during and after surgery in patients with asthma.
100 mg rectally (retention enema) nightly for 21 days or until both clinical and protological remission occurs
-Difficult cases may require 2 or 3 months of treatment
Use: As adjunctive therapy in the treatment of ulcerative colitis, especially distal forms.
