Healthy CAS 51372-29-3 Budesonide Powder For Crohn'S Disease Treatment

Oral Medical Budesonide Dexbudesonide 51372-29-3 For Treating Crohn's Disease

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Budesonide​ Introduction

Budesonide is a synthetic (man-made) steroid of the glucocorticoid family that is used for treating Crohn's disease.

Budesonide is available as a generic drug.

Budesonide is used to treat an inflammatory bowel disease called Crohn's disease. This medicine works inside the intestine(bowel) to reduce inflammation and symptoms of the disease. It also helps keep the symptoms of Crohn's disease from coming back. Budesonide is a steroid (cortisone-like) medicine.

Budesonide Usage

• Budesonide is used for the treatment of mild-to-moderately-active Crohn's disease involving the ileum (the second half of the small intestine) and/or ascending colon (the beginning of the large intestine). It is approved for maintaining remissions for up to three months.
• Budesonide also is used for the induction of remission in patients with active, mild to moderate ulcerative colitis.
• Budesonide rectal foam is used for the induction of remission in patients with active mild to moderate distalulcerative colitis extending up to 40 cm from the anus.

What is the dosage for budesonide ?

1. The recommended dose for active Crohn's disease is 9 mg once daily in the morning for up to 8 weeks.
2. The 8 week course may be repeated for recurring episodes.
3. The dose for maintenance of remission is 6 mg once daily for 3 months.
4. The recommended dosage for the induction of remission in adult patients with active, mild to moderateulcerative colitis is one 9 mg extended release tablet to be taken once daily in the morning for up to 8 weeks.
5. The recommended dose for the spray is 1 spray administered twice daily for 2 weeks followed by 1 spray once daily for 4 weeks.

Which drugs or supplements interact with budesonide ?

Medicines which block the liver enzymes that break down budesonide may lead to higher blood concentrations and more side effects of budesonide. Such medications include

• ketoconazole (Nizoral),
• fluconazole (Diflucan),
• itraconazole (Sporanox),
• clarithromycin (Biaxin),
• erythromycin,
• verapamil (for example, Calan; Isoptin; Covera HS),
• diltiazem (for example, Cardizem; Dilacor),
• ritonavir (Norvir; Kaletra),
• indinavir (Crixivan), and
• saquinavir (Invirase, Fortovase).

How does budesonide work?

The naturally-occurring hormone whose actions budesonide mimics, is cortisol or hydrocortisone which is produced by the adrenal glands.

Glucocorticoid steroids have potent anti-inflammatory actions. Crohn's disease is a chronic inflammatory bowel disease of unknown cause that results in diarrhea, crampy abdominal pain,fever and bleeding from the rectum.

The active ingredient in Budesonide, is released from granules in the ileum of the small intestine and the right (proximal) colon, where the inflammation of Crohn's disease occurs.

Budesonide acts directly by contact with the ileum and colon. Budesonide that is absorbed into the body travels first to the liver where it is broken-down and eliminated from the body.

This prevents the majority of the absorbed drug from being distributed to the rest of the body.

As a result, budesonide causes fewer severe side effects throughout the body than other corticosteroids.