Factory supply Rapamycin (AY 22989) Used as immunosuppressant 53123-88-9

Basic Information
Place of Origin: China
Brand Name: Senwayer Brand
Certification: ISO, 9001, USP
Model Number: 53123-88-9
Minimum Order Quantity: 10grams
Price: Discount is possible if your order is big enough
Packaging Details: 10g, 20g, 50g , 100g, 500g. 1kg, 10kg
Delivery Time: within 2 working days
Payment Terms: T/T in advance, Money Gram, Western Union, Bank Transfer.
Supply Ability: 1000kg/month
Detail Information
CAS: 53123-88-9 Alias: Rapamycin , AY 22989
Apparence: Almost White Crystalline Powder Purity: 99.5%
Stock: Enough Stock Grade: Pharma Grade
High Light:

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Product Description

Factory supply Rapamycin (AY 22989) Used as immunosuppressant 53123-88-9

Quick detail

CAS No.: 53123-88-9
Molecular Formula: C51H79NO13
Molecular Weight: 914.18
Appearance: White or Nearly White Crystalline Powder
Purity: 99%+
Manufacturer: Senwayer Factory


Rapamycin  Description

Rapamycin (sirolimus) is a kind of secondary metabolite produced by the soil streptomyces secretion firstly found in Chile Easter island soil in 1975, and its chemical structure belongs to "triene large ring lactone class" compounds. Due to the low rapamycin fermentation yield and complicated extraction process, until 1999, the product was developed and appeared in the market by American household chemicals company, and then gone public in a dozen countries in Europe and the United States. The U.S. food and drug administration (FDA) approved indications of rapamycin is not antibiotics but "immunosuppressant. This is because rapamycin showed a strong immunosuppressive effect in clinical trials, and can replace ring spore which has a clinical history more than 30 years. And compared with ring spore, the oral dose of rapamycin is smaller (only take 2~3 mg each time), anti-rejection effect is stronger, and less side effects. So since rapamycin listed, it was quickly used as common oral immune inhibitors for transplants in the world.


Targeted Cancer Therapy Drugs

In recent years, studies found that as an intracellular kinase, the pathway abnormality of rapamycin target protein (mTOR) may induce many diseases. Rapamycin as mTOR’s targeted inhibitor, can treat the tumors closely related to the pathway including kidney cancer, lymphoma, lung cancer, liver cancer, breast cancer, neuroendocrine carcinoma and gastric cancer, etc. Especially for LAM (lymphatic fibroid disease) and TSC tuberous sclerosis-the treatment effect of the two kinds of rare diseases is more apparent, and to some extent LAM and TSC can be considered as tumor diseases.


Rapamycin  Usage

  • Uses Used as immunosuppressant.
  • Usage A specific mTOR inhibitor with an IC50 of 0.1 nM.
  • Usage antidepressant
  • Usage immunosuppressant, antineoplastic; rapamycin
  • Usage DDP-4 inhibitor type 2 diabetes therapeutic
  • Usage Labelled Rapamycin. A triene macrolide antibiotic isolated from Streptomyces hygroscopicus. Name derived from the native word for Easter Island, Rapa?Nui. Used as an immunosuppressant; antirestenotic. This compound contains aproximately 2% d0.;Labeled Sir


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