|Place of Origin:||China|
|Certification:||ISO 9001, GMP, USP, BP, CP|
|Minimum Order Quantity:||100g|
|Price:||Discount is possible if your order is big enough|
|Packaging Details:||foil bag|
|Delivery Time:||within 3 workdays|
|Payment Terms:||T/T in advance, Money Gram, Western Union, Bank Transfer., L/C|
|Appearance:||Powder||Grade Standard:||Medicine Grade|
38183-03-8 7 8 - Dihydroxy Flavones,
8 - Dihydroxy Flavones White Crystalline Powder
Name: 7,8-DIHYDROXY FLAVONE
English synonym: 7,8-DHF
CAS number: 38183-03-8
Molecular formula: C15H10O4
Molecular weight: 254.24
EINECS Number: 253-812-4
Melting point: 243-246°C
Boiling point: 494.4±45.0°C (Predicted)
Storage conditions: Inert atmosphere, Room Temperature
Solubility: DMSO:soluble 24mg/mL
Acidity coefficient (pKa): 6.86±0.40 (Predicted)
7,8-Dihydroxyflavone (7,8-DHF) is a potent and selective TrkB receptor agonist (Kd≈320 nM). The TrkB receptor is the major signaling receptor for brain-derived neurotrophic factor. 7,8-Dihydroxyflavone is a biologically effective compound. After intraperitoneal injection or oral administration to mice, 7,8-Dihydroxyflavone can cross the blood-brain barrier and activate TrkB and its downstream PI3K/Akt and MAPK. 7,8-DHF promotes the viability of cortical neurons and reduces their apoptosis in traumatic brain injury. 7,8-DHF was administered 3 hours after injury, and 7,8-DHF could reduce tissue damage through the PI3K/Akt signaling pathway. Treatment with 7,8-DHF did not induce any significant toxic effects in mice, and chronic administration was not toxic to mice. 7,8-DHF has a strong therapeutic effect on Alzheimer's disease and can inhibit obesity by activating muscle TrkB.
Packaging & Shipping
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7. For mass order,please allow 5-8 days by air,15-30 days by sea.