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Parmaceutical Fasudil Hydrochloride Intermediate CAS 505-66-8 Homopiperazine Powder

Basic Information
Place of Origin: China
Brand Name: Senwayer Brand
Certification: ISO, 9001, USP
Model Number: 505-66-8
Minimum Order Quantity: 10grams
Price: Discount is possible if your order is big enough
Packaging Details: 10g, 20g, 50g , 100g, 500g. 1kg, 10kg
Delivery Time: within 2 working days
Payment Terms: T/T in advance, Money Gram, Western Union, Bank Transfer.
Supply Ability: 1000kg/month
Detail Information
CAS: 505-66-8 Apparence: Almost White Crystalline Powder
Purity: 99% Usage: Fasudil Hydrochloride Intermediate
Stock: Enough Stock Packing: As Your Requirement
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Product Description

Parmaceutical Fasudil Hydrochloride Intermediate CAS 505-66-8 Homopiperazine Powder

 

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​Homopiperazine

CAS No.: 505-66-8
Synonyms:

hexahydro-1H-1,4-diazepine; 1,4-diazacycloheptane; HPRZ; 1H-1,4-Diazepine, hexahydro-; 1,4-Diazacycloheptane,2,3,4,5,6,7-Hexahydro-1H-1,4-diazepine;
High-piperazine; homopiperazine; hexahydro-4H-1,4-diazepine; hexahydro-1,4-diazepine; Homo-Piperazines; tetrahydro-1,4-diazepine; HOJNEYSUCKLEEXTRACT;

Formula: C5H12N2
Exact Mass: 100.10000
Molecular Weight: 100.16200
PSA: 24.06000
LogP: 0.22690

 

Description


Homopiperazine is a nitrogen-containing seven-membered ring hetero-atomic compound and is an important pharmaceutical intermediate. The majority of its derivatives has strong biological activity and medicinal value and can be used for synthesizing homopiperazine hydrochloride, cyclizine, carbamazepine, chlorcyclizine and other drugs. Western medicine often takes homopiperazine as raw material for the modified quinoline and isoquinoline derivatives, quinolone derivative, thiazolidine carboxylic acid amide derivatives and other drugs, and for the synthesis of pyridazine, nitroxyl-containing benzylamine derivatives, water-soluble azole and other drugs which has good efficacy for the treatment of cardiovascular disease, interstitial plasma cell pneumonia especially for AIDS patients with Pneumocystis pneumonia, asthma, central nervous system disorders including depression and anxiety disorders. For example, 1-(5-isoquinoline-sulfonyl) homopiperazine hydrochloride is effective in the treatment of symptoms such as chronic angina disease, vitiligo, depression, anxiety, cerebral vasospasm and cerebral vasospasm caused cerebral ischemia and other symptoms.

 

Usage


It can be used as organic and pharmaceutical synthesis intermediates, for example, being applied to the synthesis of fasudil hydrochloride.
Homopiperazine acts as a corrosion inhibitor for iron. It has also been used in the preparation of potent H3 receptor antagonists for use as treatments for neurodegenerative conditions such as Alzheimer disease.

 

Properties

Appearance & Physical State:

The white solid (30ºC) or colorless viscosity liquids (30ºCand above)

Density:

0.861g/cm3

Melting Point:

38-40ºC

Boiling Point:

169ºC

Flash Point:

64ºC

 

Parmaceutical Fasudil Hydrochloride Intermediate CAS 505-66-8 Homopiperazine Powder 0

 

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