| Place of Origin: | China |
|---|---|
| Brand Name: | Senwayer Brand |
| Certification: | ISO, 9001, USP |
| Model Number: | 505-66-8 |
| Minimum Order Quantity: | 10grams |
| Price: | Discount is possible if your order is big enough |
| Packaging Details: | 10g, 20g, 50g , 100g, 500g. 1kg, 10kg |
| Delivery Time: | within 2 working days |
| Payment Terms: | T/T in advance, Money Gram, Western Union, Bank Transfer. |
| Supply Ability: | 1000kg/month |
| CAS: | 505-66-8 | Apparence: | Almost White Crystalline Powder |
|---|---|---|---|
| Purity: | 99% | Usage: | Fasudil Hydrochloride Intermediate |
| Stock: | Enough Stock | Packing: | As Your Requirement |
| High Light: | pharmaceutical raw material,medical raw material |
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Parmaceutical Fasudil Hydrochloride Intermediate CAS 505-66-8 Homopiperazine Powder
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Homopiperazine |
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| CAS No.: | 505-66-8 |
| Synonyms: |
hexahydro-1H-1,4-diazepine; 1,4-diazacycloheptane; HPRZ; 1H-1,4-Diazepine, hexahydro-; 1,4-Diazacycloheptane,2,3,4,5,6,7-Hexahydro-1H-1,4-diazepine; |
| Formula: | C5H12N2 |
| Exact Mass: | 100.10000 |
| Molecular Weight: | 100.16200 |
| PSA: | 24.06000 |
| LogP: | 0.22690 |
Description
Homopiperazine is a nitrogen-containing seven-membered ring hetero-atomic compound and is an important pharmaceutical intermediate. The majority of its derivatives has strong biological activity and medicinal value and can be used for synthesizing homopiperazine hydrochloride, cyclizine, carbamazepine, chlorcyclizine and other drugs. Western medicine often takes homopiperazine as raw material for the modified quinoline and isoquinoline derivatives, quinolone derivative, thiazolidine carboxylic acid amide derivatives and other drugs, and for the synthesis of pyridazine, nitroxyl-containing benzylamine derivatives, water-soluble azole and other drugs which has good efficacy for the treatment of cardiovascular disease, interstitial plasma cell pneumonia especially for AIDS patients with Pneumocystis pneumonia, asthma, central nervous system disorders including depression and anxiety disorders. For example, 1-(5-isoquinoline-sulfonyl) homopiperazine hydrochloride is effective in the treatment of symptoms such as chronic angina disease, vitiligo, depression, anxiety, cerebral vasospasm and cerebral vasospasm caused cerebral ischemia and other symptoms.
Usage
It can be used as organic and pharmaceutical synthesis intermediates, for example, being applied to the synthesis of fasudil hydrochloride.
Homopiperazine acts as a corrosion inhibitor for iron. It has also been used in the preparation of potent H3 receptor antagonists for use as treatments for neurodegenerative conditions such as Alzheimer disease.
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Properties |
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Appearance & Physical State: |
The white solid (30ºC) or colorless viscosity liquids (30ºCand above) |
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Density: |
0.861g/cm3 |
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Melting Point: |
38-40ºC |
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Boiling Point: |
169ºC |
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Flash Point: |
64ºC |
