| Place of Origin: | China |
|---|---|
| Brand Name: | Senwayer Brand |
| Certification: | ISO, 9001, USP |
| Model Number: | 32981-86-5 |
| Minimum Order Quantity: | 10grams |
| Price: | Discount is possible if your order is big enough |
| Packaging Details: | 10g, 20g, 50g , 100g, 500g. 1kg, 10kg |
| Delivery Time: | within 2 working days |
| Payment Terms: | T/T in advance, Money Gram, Western Union, Bank Transfer. |
| Supply Ability: | 1000kg/month |
| CAS: | 32981-86-5 | Apparence: | White Powder |
|---|---|---|---|
| Purity: | 99% | Other Name: | 10-Deacetylbaccatin III, 10-DAB-III |
| Usage: | Cancer Cure | Grade: | Pharma Grade |
| High Light: | anti cancer drugs,antineoplastic drugs |
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Miscellaneous Natural Cancer Cure Drugs 10-Deacetylbaccatin III CAS 32981-86-5
Quick detail
| Name: | 10-Deacetylbaccatin |
| CAS No.: | 32981-86-5 |
| Formula: | C29H36O10 |
| Molecular Weight: | 544.60 |
| Synonyms: | DESACETYLBACCATINE;BACCATIN III, 10-DEACETYL-;10-O-DEACETYLBACCATIN III;10-DAB-III;10-DEACETYLBACCATIN;12b-(Acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-4,6,9,11-tetrahydroxy-4a,8,13,13-tetramethyl-7,11-methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one;10-deacetylbaccatin11;10-deacetylbaccatiniii(extaxusbaccata) |
| Density: | 1.41 g/cm3 |
| Melting Point: | 231-236 °C |
| Boiling Point: | 716.8 °C at 760 mmHg |
| Flash Point: | 233.5 °C |
| Solubility: | Insoluble in water |
| Appearance: | white solid |
| Hazard Codes | T |
| Risk Statements | 23/24/25 |
| Safety Statements | 45-38-36/37/39-28A |
| RIDADR | 1544 |
| WGK Germany | 3 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
10-Deacetylbaccatin III Description:
| 1 | 10-Deacetylbaccatin III is a natural organic compound isolated from the bark of the Pacific yew tree (Taxus brevifolia) and related species. |
| 2 | 10-Deacetylbaccatin III is used as a chemical intermediate in the preparation of the anti-cancer drug paclitaxel. |
| 3 | 10-Deacetylbaccatins are a series of closely related natural organic compounds isolated from the Pacific yew tree (Taxus brevifolia) and related species. |
| 4 | 10-Deacetylbaccatin III is a precursor to the anti-cancer drug docetaxel (Taxotere) |
| 5 | 10-deacetylbaccatin III 10-O-acetyltransferase converts 10-deacetylbaccatin to baccatin III: |
10-Deacetylbaccatin III Usage
| Usage |
10-DAB (10-Deacetylbaccatin) is an antineoplastic agent and an anti-cancer intermediate. 10-DAB (10-Deacetylbaccatin) has gained great attention because of its partly excellent anti-cancer properties. 10-DAB (10-Deacetylbaccatin) can be gained from the le |
| Usage | 10-Deacetyl Baccatin III is an impurity of Paclitaxel (P132500) and derivatives. |
| Usage | A intermediate in the synthesis of Taxol and derivatives |
Biological Activity
10-deacetylbaccatin III is an intermediate in the biosynthetic pathway of the taxane, paclitaxel. Taxanes disrupt mitosis by preventing microtubule destabilization and spindle fiber formation in animal cells (Molè-Bajer, 1983). As a consequence of this mechanism, yew trees are slow growing organisms. Without mitosis, cells, especially cells with a high replication rate such as tumor cells, cannot divide. Taxanes are currently being investigated as possible treatment for certain cancers, and paclitaxel, is currently approved by the FDA for treatment of AIDS-related Karposi sarcoma, breast cancer, non-small cell lung cancer, and ovarian cancer.
