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|Apparence:||Almost White Crystalline Powder||Purity:||99.5%|
|Stock:||Enough Stock||Grade:||Pharma Grade|
Trilostane CAS 13647-35-3 Anti Estrogen Steroids Treatment of Cushing's Syndrome
|Synonyms:||Trilostane; Vetoryl; Modrastane; Desopan; modrenal; Modrefen;|
|Boiling Point:||516.5ºC at 760 mmHg|
|Vapor Pressure:||5.39E-12mmHg at 25°C|
Trilostane is an enzyme inhibiting medication. Its principal use is in the treatment of canine Cushing’s disease. In some cases, trilostane may also be an appropriate treatment for horses, cats and other conditions.
Trilostane is an inhibitor of 3β-hydroxysteroid dehydrogenase used in the treatment of Cushing's syndrome and primary hyperaldosteronism. These are both disorders where excess amounts of corticosteroid hormones are produced in the body. Corticosteroids are essential for the body to make use of carbohydrates, fats and proteins and for a normal response to stress.
Trilostane can also be useful in the treatment of breast cancer that has relapsed in women who have gone through menopause.
Trilostane Uses in dogs
It is also the first drug approved to treat both pituitary-and adrenal-dependent Cushing's in dogs.
|1.||It has kidney or liver disease.|
|2.||takes certain medications used to treat heart disease.|
|4.||taking other medicines, including those available to buy without a prescription, herbal or complementary medicines.|
|5.||had an allergic reaction to this or any other medicine.|
Trilostane — Drug Interactions and Potential Side Effects
Potential side effects include vomiting, reduced appetite, weight loss, diarrhea and tiredness. Rare instances of death have been reported. As each patient reacts differently to trilostane, arriving at the appropriate dosage is crucial in preventing instances of overdose and achieving the best possible outcome.
|Melting point||257°C to 270°C||261°C -266°C|
|Appearance||White to pale white solid||White solid|
|Heavy metals||No more than 20ppm||10ppm|
|Loss on drying||Not more than 0.5%||0.18%|
|Residue on Ignition||Not more than 0.1%||0.02%|
soluble in dimethyl sulfoxide
|Assay (microbial)||Not less than 99.0%||99.5%|
|Related impurities||not more than 1.0%||0.35%|
|HPLC purity||not less than 99.0%||99.6%|
|Conclusion||Comply with In-house standard.|
|Storage||Store protected from light and moisture|