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CAS 461432-26-8 Active Pharmaceutical Ingredients Dapagliflozin For SGLT2 inhibitors

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CAS 461432-26-8 Active Pharmaceutical Ingredients Dapagliflozin For SGLT2 inhibitors

China CAS 461432-26-8 Active Pharmaceutical Ingredients Dapagliflozin For SGLT2 inhibitors supplier
CAS 461432-26-8 Active Pharmaceutical Ingredients Dapagliflozin For SGLT2 inhibitors supplier CAS 461432-26-8 Active Pharmaceutical Ingredients Dapagliflozin For SGLT2 inhibitors supplier

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Product Details:

Place of Origin: China
Brand Name: Jusheng Brand
Certification: ISO, 9001, USP
Model Number: 461432-26-8

Payment & Shipping Terms:

Minimum Order Quantity: 10grams
Price: Discount is possible if your order is big enough
Packaging Details: 10g, 20g, 50g , 100g, 500g. 1kg, 10kg
Delivery Time: within 2 working days
Payment Terms: T/T in advance, Money Gram, Western Union, Bank Transfer.
Supply Ability: 1000kg/month
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Detailed Product Description
CAS: 461432-26-8 Apparence: White Powder
Purity: 99% Other Name: Dapagliflozin; [14C]-Dapagliflozin;
Stock: Enough Stock Grade: Pharma Grade

Dapagliflozin CAS 461432-26-8 Active Pharmaceutical Ingredients For SGLT2 inhibitors

 

Quick detail


Dapagliflozin
CAS No.:

461432-26-8

Synonyms:

Dapagliflozin; [14C]-Dapagliflozin;

D-Glucitol,1,5-anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-,(1S);Forxiga (TN); (2S,3R,4R,5S,6R)-2-[4-chloro-3-(4-ethoxybenzyl)phenyl]-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol;dapaglifozin; (2S,3R,4R,5S,6R)-2-[4-chloro-3-(4-ethoxybenzyl)phenyl]-6-(hydroxymethy)tetrahydro-2H-pyran-3,4,5-triol;(2S,3R,4R,5S,6R)-2-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-6 (hydroxymethyl)oxane-3,4,5-triol;

Formula: C21H25ClO6
Exact Mass: 408.13400
Molecular Weight: 408.87300
PSA: 99.38000
LogP: 1.84440
Properties
Density: 1.349
Boiling Point: 609ºC at 760mmHg
Flash Point: 322.1ºC
Refractive Index: 1.614

 

Dapagliflozin Description


Dapagliflozin is used along with diet and exercise, and sometimes with other medications, to lower blood sugar levels in patients with type 2 diabetes (condition in which blood sugar is too high because the body does not produce or use insulin normally). Dapagliflozin is in a class of medications called sodium-glucose co-transporter 2 (SGLT2) inhibitors. It lowers blood sugar by causing the kidneys to get rid of more glucose in the urine. Dapagliflozin is not used to treat type 1 diabetes (condition in which the body does not produce insulin and, therefore, cannot control the amount of sugar in the blood) or diabetic ketoacidosis (a serious condition that may develop if high blood sugar is not treated).

 

Over time, people who have diabetes and high blood sugar can develop serious or life-threatening complications, including heart disease, stroke, kidney problems, nerve damage, and eye problems. Taking dapagliflozin, making lifestyle changes (e.g., diet, exercise, quitting smoking), and regularly checking your blood sugar may help to manage your diabetes and improve your health. This therapy may also decrease your chances of having a heart attack, stroke, or other diabetes-related complications such as kidney failure, nerve damage (numb, cold legs or feet; decreased sexual ability in men and women), eye problems, including changes or loss of vision, or gum disease. Your doctor and other healthcare providers will talk to you about the best way to manage your diabetes.

 

Dapagliflozin Pharmacological effects


Pharmacological effects Dapagliflozin works through inhibiting sodium-glucose transporter 2 (SGLT2), a protein in the kidney that reabsorbs glucose into the bloodstream. This allows extra glucose to be excreted through the urine, improving glycemic control without increasing insulin secretion. The use of this drug requires patients with normal renal function while patients of moderate to severe renal insufficiency should be disabled to use this drug. Single application of this product or combination with metformin, pioglitazone, glimepiride, insulin and other drugs can significantly reduce the HbA1c and fasting blood glucose of patients suffering type II diabetes. The frequency of the adverse reaction was similar to placebo with low risk of hypoglycemia, being able to reduce body weight.
The efficacy of dapagliflozin is comparable with the dipeptidyl peptidase inhibitors, and several new hypoglycemic drugs, and can also mildly lower the blood pressure and body weight. The drug has 5mg and 10mg two tablets to choose from, can be either used alone or together with insulin, including other diabetes drugs.

 

CAS 461432-26-8 Active Pharmaceutical Ingredients Dapagliflozin For SGLT2 inhibitors 

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