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|Apparence:||Almost White Crystalline Powder||Purity:||99%|
Articaine Legal Anti Paining Local Anesthetic Drugs Articaine HCL CAS 23964-57-0
|Synonyms:||2-Thiophenecarboxylicacid, 4-methyl-3-[2-(propylamino)propionamido]-, methyl ester (8CI);Carticaine;|
|Boiling Point:||440.6 °C at 760 mmHg|
|Flash Point:||220.3 °C|
|Appearance:||White or white crystalline powder|
Articaine is an intermediate-potency, short-acting amide local anesthetic with a fast metabolism due to an ester group in its structure. It is effective with local infiltration or peripheral nerve block in dentistry, when administered as a spinal, epidural, ocular, or regional nerve block, or when injected intravenously for regional anesthesia.
In comparative trials, its clinical effects were not generally significantly different from those of other short-acting local anesthetics like lidocaine, prilocaine, and chloroprocaine, and there is no conclusive evidence demonstrating above-average neurotoxicity. Articaine proved to be suitable and safe for procedures requiring a short duration of action in which a fast onset of anesthesia is desired, eg, dental procedures and ambulatory spinal anesthesia, in normal and in special populations.
Articaine is a local anaesthetic that has been approved overseas for several years. Like other amide anaesthetics, articaine blocks nerve conduction when it is infiltrated around a nerve. This action is prolonged by combining the drug with a vasoconstrictor .
The combination of articaine can be used for local or regional anaesthesia for dental procedures. Anaesthesia begins within six minutes and lasts for an hour. The half-life of articaine is approximately 1.8 hours. It is metabolised and then mainly excreted in the urine.
|Items of analysis||Specification||Results|
|Appearance||A white or almost white crystalline power||A white crystalline power|
|Solubility||Freely soluble in water and in alcohol||Complies|
|Appearance of solution||≤BY6||Complies|
|Clarity||Solution should be clear||Complies|
Impurity A ≤0.2%;
Any other impurity ≤0.1%
Total of other impurities ≤0.5%
|Loss on drying||＜0.5%||0.09%|
|Resiue on ignition||≤0.1%||0.09%|