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|CAS:||84449-90-1||Apparence:||Light Yellow Powder|
|Purity:||99%||Storage:||Shading, Confined Preservation|
|Usage:||Cancer Treatment Steroids||Stock:||Enough Stock|
Medical Raloxifene 84449-90-1 Female Anti Estrogen And Cancer Treatment Steroids
CAS No.: 84449-90-1
Molecular Weight: 473.58
Synonyms: Keoxifene;LY 139481;[2-(4-Hydroxyphenyl)-6-hydroxybenzo[b]thien-3-yl][4-(2-(1-piperidinyl)ethoxy)phenyl]methanone;
Density: 1.289 g/cm3
Melting Point: 250-253 °C
Boiling Point: 728.2 °C at 760 mmHg
Flash Point: 394.2 °C
Solubility: DMSO: 28 mg/mL, soluble
Appearance: light-yellow solid
Product Categories: Raloxifene;Intermediates & Fine Chemicals;Pharmaceuticals;Pharmaceutical intermediate
Usage : A nonsteroidal estrogen receptor mixed agonist/antagonist
Raloxifene, a member of the class of selective estrogen receptor modulators (SERM), reproduces the beneficial effects of estrogens on the skeletal systems, without the negative effects estrogens on breast and endometrium.
This is a review article summarizing its mechanism, effects on bone and its applicability in traumatology clinical practice. In postmenopausal osteoporosis, this drug has been proven to decrease accelerated bone turnover, increase bone mineral density (BMD), and to structurally recover bone, decreasing the risk of vertebral fractures and the risk of non-vertebral fractures in patients with previous, severe vertebral fractures.
Moreover, raloxifene appears to lower the risk of invasive breast cancer. Raloxifene would be efficacious in the prevention and treatment of postmenopausal osteoporosis.
We can therefore conclude that raloxifene would be efficacious in the prevention and treatment of postmenopausal osteoporosis, while reducing the risk of breast cancer when used at the indicated dose of 60 mg/day and with a low incidence of side effects.
Before taking raloxifene,
Certificate of Analysis
|Appearance||White &off-white powder||Conforms|
|Grade||Anti Estrogen Steroids||Conforms|
|Solubility||Soluble in 10% sodium hydroxide solution. Slightly Soluble in methanol. Insoluble in water||Conforms|
|Loss on drying||≤0.5%||0.4%|
|Residue on ignition||≤0.1%||0.06%|
|Raloxifene Impurity1||≤0.20 %||0.10%|
|Any unspecified individual impurity 2||≤0.10%||Max. 0.08%|