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|CAS:||96829-58-2||Alias:||Orlistat , Orlipastat , Tetrahydrolipstatin|
|Apparence:||Almost White Crystalline Powder||Purity:||99%|
|Usage:||Fat Killer Drugs||Stock:||Enough Stock|
Safety Fat - Killer Supplement Orlistat 96829-58-2 Bodybuilder Tetrahydrolipstatin
CAS Numbers: 96829-58-2
Appearance: white needle crystal or powder
Quality standard: CP
Packing specification: 1 kg/bag, 25kg / drum .
Melting point: 45
Appearance: White or kind of white crystalline powder, soluble in water.
Manufacturer: Jusheng Factory.
Orlistat ( also known as tetrahydrolipstatin ) is a drug designed to treat obesity . Its primary function is preventing the absorption of fats from the human diet by acting as a lipase inhibitor , thereby reducing caloric intake . It is intended for use in conjunction with a healthcare provider-supervised reduced-calorie diet .
Orlistat is the saturated derivative of lipstatin , a potent natural inhibitor of pancreatic lipases isolated from the bacterium Streptomyces toxytricini . However , due to its relative simplicity and stability , orlistat was chosen over lipstatin for development as an anti-obesity drug .
The drug does not need to be absorbed through the body. At normal doses, the absorption of fat can be inhibited by 30%. There is little absorption after oral administration. It can be subject to metabolic inactivation in the intestine with the metabolic sites located in the gastrointestinal wall. The elimination half-life is about 14 to 19 hours. About 97% of the goods are excreted with the feces, of which 83% are in the prototype.
Clinically orlistat can be applied to the treatment of obesity and hyperlipidemia. Under normal circumstances, it can be subject to oral administration at a dose of 120 mg for three times per day. Take it during the meal or 1 hour after a meal. After 2 weeks of administration, the body weight can begin to decline. It can be taken continuously for 6 to 12 months. If the dose is increased to above 400 mg daily, the effect will no longer be further enhanced.
Avoid a diet that is high in fat . High-fat meals taken in combination with orlistat can increase your risk of unpleasant side effects on your stomach or intestines .
If you also take cyclosporine , do not take it within 3 hours before or 3 hours after you take orlistat .
If you also take levothyroxine ( such as Synthroid ) , do not take it within 4 hours before or 4 hours after you take orlistat .
Orlistat Recommended Dose
Adults: The recommended dose is taking a 120 mg capsule during meal or within one hour after meal. If a meal is not into the food or no fat, you can omit a medication. Long-term use of treatment (including weight control and risk factors for improvement) is sustainable.
The patient's diet should be nutritionally balanced with slightly low heat. There is about 30% of heat coming from fat. The food should be rich in fruits and vegetables. The intake of fats, carbohydrates and protein should be distributed in three meals a day. There is no evidence that over three times daily /120mg per time can enhance the efficacy. No dose adjustment is required for the elderly.
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|1 .||Orlistat is a drug that promotes loss of weight by preventing the digestion and absorption of fat in food. In the intestine, an enzyme called lipase (produced primarily by the pancreas) breaks apart fat in food so that it can be absorbed into the body|
|2 .||Orlistat blocks the action of lipase and thereby prevents the breakup and absorption of fat. Orlistat blocks absorption of about 25% of the fat in a meal. The unabsorbed fat is excreted in the stool.|
|3 .||Orlistat is the saturated derivative of lipstatin, a potent natural inhibitor of pancreatic lipases isolated from the bacterium Streptomyces toxytricini. However, due to its relative simplicity and stability, orlistat was chosen over lipstatin for development as an anti-obesity drug|
|4 .||Dietary fats need to be broken down into smaller pieces before the body can absorb them. Orlistat works by blocking the enzyme that breaks down fats in your diet. This undigested fat then passes out of your body in your bowel movement|
|5 .||Orlistat does not block the absorption of calories from sugar and other non-fat foods, so you still need to restrict your total intake of calories|
|6 .||Orlistat is notorious for its gastrointestinal side effects (sometimes referred to as treatment effects), which can include steatorrhea (oily, loose stools). In the United States and the European Union, orlistat is available for sale without a prescription. Generic formulations of orlistat are available in some countrie|
|Outer Packing||1kg/foil bag|
|Production date||March 1th, 2017|
|Shelf life||Feb 29th, 2017|
|Standard adopted||In-house Standard|
|TLC||only one spot||Conforms|