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|CAS:||54965-24-1||Alias:||Tamoxifen Citrate, Nolvadex|
|Apparence:||Almost White Crystalline Powder||Purity:||99%|
Effective Tamoxifen Citrate Prevention of Breast Cancer 54965-24-1Nolvadex Powder
Tamoxifen citrate(Tamoxifen, abbreviation TCT ), is an estrogen competitive antagonist and non-steroidal anti-estrogen drug. It can compete with estrogen (estradiol) to combine with estrogen receptor of breast cancer cells, inhibiting the effect of estrogen on cancer cells, and stunting growth and development of tumor cells to show anticancer effects. Clinically Tamoxifen citrate is commonly used to treat various types of breast cancer, especially for postmenopausal breast cancer women with the positive of estrogen receptor and progesterone receptor and with low prostate-specific antigen levels.
1. Treatment of breast cancer.
2. Prevention of breast cancer.
3. Anti-tumor and anti-multidrug resistance.
By reducing membrane negotiability and enhancing rigidity of inter-cell binding site, Tamoxifen citrate can reduce concentration and activity of cancer metastasis promoter and various activating enzymes, so as to inhibit or hinder growth and metastasis of cancer cell. In addition, it can promote cells surrounding tumor focus to secrete a negative growth factor-transforming growth factor TGF-G, inhibiting multiply indefinitely of cancer cells; inhibiting oxidative damage of DNA bases which is caused by hydrogen peroxide generated from human neutrophils. So except for breast cancer, it is good for treatment and prevention of other malignant neoplasms, and is used for treatment of brain tumors, liver cancer, prostate cancer, etc. In addition, Tamoxifen citrate can reduce release effect of membrane P170 glycoprotein through reducing membrane negotiability, improving intracellular effective concentration of cytotoxic drug and reducing drug resistance.
4. Heart protection.
5. For the treatment of advanced and recurrent breast cancer and ovarian cancer
6. Anti-estrogen, protein kinase C inhibitor, beneficial cardiovascular effects, bone cancer treatment, induces DNA adduct formation
Tamoxifen citrate COA:
|Results Of Analysis Tests|
|Appearance||White or almost white powder||Conforms|
|Identification||UV conforms to RS||conforms|
|Loss on drying||≤0.5%||0.21%|
|Residue on ignition||≤0.2%||0.06%|
|Related substances||Total: Not more than 1.0%||0.32%|
|Individual: Not more than 0.5%||0.14%|
|Organic volatile impurities||conforms||conforms|
|Conclusion||Conform with USP 30|
|Letrozole Femara||CAS 112809-51-5|
|Tamoxifen Citrate Novadex||CAS 54965-24-1|
|Clomifene citrate Serophene||CAS 50-41-9|
|Anastrozole Arimidex||CAS 120511-73-1|
|Exemestane Aromasin||CAS 107868-30-4|
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