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|CAS:||53-43-0||Alias:||Dehydroepiandrosterone, DHEA, PRASTERONE|
|Apparence:||Almost White Crystalline Powder||Purity:||99%|
Raw Dehydroepiandrosterone DHEA Anti-cancer 53-43-0 Enhance Immune System Drugs
|Product Categories:||Pharmaceutical Intermediates;Steroids;17-Ketosteroids;Biochemistry;Hydroxyketosteroids; Nutritional Supplements;Intermediates & Fine Chemicals; Pharmaceuticals;Steroid and Hormone; API;Inhibitors|
|Anti-cancer:||DHEA has a certain role on the prevention and inhibition of tumor growth. The first clinical discovery of anti-cancer effect of prasterone and reverse breast cancer. Clinically, prasterone anticancer effects and reversal of breast cancer are related. Low levels of prasterone are associated with bladder cancer and gastric cancer, and are not associated with age. It has been confirmed that DHEA has protective and synergistic effects for the treatment of tumors. DHEA has the effect of inhibiting 5-phosphate ribose, so prasterone could inhibit cancer by inhibiting excessive mitochondria (NADPH) and 5-phosphate ribose esters. DHEA could inhibit the growth of pancreatic cancer cells. It is presumed that the mechanism is that DHEA inhibits the growth of pancreatic cancer cells by regulating the alternation of estrogen concentrations in plasma.|
DHEA could restore the damaged immune response, and improve immune function of T cell and B cell. DHEA plays an important role in improving the physiological activity of insulin-like growth factor (IGF-1). It is a potentially beneficial drug for the treatment of immunodeficiency.
|Effect on sclerotin:||
prasterone itself can not affect the growth and differentiation of human osteoblasts directly, but can affect the growth and differentiation of osteoblasts by affecting the changes of 1, 25-dihydroxyvitamin D3. The effect of DHEA on sclerotin depends on the form of existence of sex hormones in osteocytes and their endocrine effects on osteoblasts.
Dehydroepiandrosterone Side Effect :
As a hormone precursor, there has been a smattering of reports of side effects possibly caused by the hormone metabolites of DHEA.
It is not known whether DHEA is safe for long-term use. Some researchers believe DHEA supplements might actually raise the risk of breast cancer, prostate cancer, heart disease, diabetes, and stroke. DHEA may stimulate tumor growth in types of cancer that are sensitive to hormones, such as some types of breast, uterine, and prostate cancer. DHEA may increase prostate swelling in men with benign prostatic hyperplasia (BPH), an enlarged prostate gland.
DHEA is a steroid hormone. High doses may cause aggressiveness, irritability, trouble sleeping, and the growth of body or facial hair on women. It also may stop menstruation and lower the levels of HDL ("good" cholesterol), which could raise the risk of heart disease. Other reported side effects include acne, heart rhythm problems, liver problems, hair loss (from the scalp), and oily skin. It may also alter the body's regulation of blood sugar.
DHEA should not be used with tamoxifen, as it may promote tamoxifen resistance. Patients on hormone replacement therapy may have more estrogen-related side effects when taking DHEA. This supplement may also interfere with other medicines, and potential interactions between it and drugs and herbs should be considered. Always tell your doctor and pharmacist about any supplements and herbs you are taking.
DHEA is possibly unsafe for individuals experiencing the following conditions: pregnancy and breast-feeding, hormone sensitive conditions, liver problems, diabetes, depression or mood disorders, polycystic ovarian syndrome (PCOS), or cholesterol problems. Individuals experiencing any of these conditions should consult with a doctor before taking.
How Does It Work?
DHEA is a "parent hormone" produced by the adrenal glands near the kidneys and in the liver. In men, DHEA is also secreted by the testes. It is changed in the body to a hormone called androstenedione. Androstenedione is then changed into the major male and female hormones.
DHEA levels seem to go down as people get older. DHEA levels also seem to be lower in people with certain conditions like depression. Some researchers think that replacing DHEA with supplements might prevent some diseases and conditions.
How to Take It:
If you are under 40, you shouldn't take DHEA without your doctor's supervision. Your doctor can determine whether your DHEA levels are low (less than 130 mg/dl in women and less than 180 mg/dl in men).
Don't give DHEA to a child unless your child's doctor tells you to.
The dose of DHEA may depend on a person's gender, age, and condition. Laboratory tests can assess your DHEA levels before you take it, and can monitor levels after you start. Talk to your doctor to find the right dose for you.
Higher doses have been used to treat lupus. People with lupus should not take DHEA without first talking to their doctor.
Your body makes DHEA primarily in the morning, so taking DHEA in the morning will mimic this natural rhythm