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|Apparence:||Almost White Crystalline Powder||Purity:||99.5%|
Anti-cancer Doxorubicin hydrochloride 25316-40-9 Raw Material Drug API Powder
Product name: Doxorubicin hydrochloride
Usage: Topoisomerase II inhibitor. Antibiotic with cytotoxic actions.
Appearance: A red-orange, crystalline powder
Solubility. Soluble in DMSO to 25 mM and in water to 50 mM
Category: Cytotoxic drug
Storage: Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Jusheng Packing: 1)Aluminum Foil Bag: 100g, 500g, 1Kg 2)Fiber Drum: 25Kg
Jusheng Delivery Method: HKEMS, DHL, TNT, UPS, FEDEX, EMS, China Air Post etc.
Jusheng Clearance Rate: 100% Custom Pass, Diguised Package and Safe Delivery
Jusheng Delivery Time: 5-14 Working Days, Tracking Number Available
Jusheng Payment Terms: T/T, MoneyGram, Western Union and Bitcoin
Jusheng Origin: Hubei Province, China
Jusheng Brand Name: Jusheng Brand
Jusheng Production Capacity: 1000Kg/Month
Doxorubicin Hydrochloride is the hydrochloride salt of doxorubicin, an anthracycline antibiotic with antineoplastic activity. Doxorubicin, isolated from the bacterium Streptomyces peucetius var. caesius, is the hydroxylated congener of daunorubicin. Doxorubicin intercalates between base pairs in the DNA helix, thereby preventing DNA replication and ultimately inhibiting protein synthesis. Additionally, doxorubicin inhibits topoisomerase II which results in an increased and stabilized cleavable enzyme-DNA linked complex during DNA replication and subsequently prevents the ligation of the nucleotide strand after double-strand breakage. Doxorubicin also forms oxygen free radicals resulting in cytotoxicity secondary to lipid peroxidation of cell membrane lipids; the formation of oxygen free radicals also contributes to the toxicity of the anthracycline antibiotics, namely the cardiac and cutaneous vascular effects.
1. Hodgkin's disease and lymphosarcoma, reticulum cell sarcoma.
2. undifferentiated small cell and non-small cell lung cancer, breast cancer.
3. acute lymphoblastic and myeloid leukemia.
4. osteosarcoma and soft tissue sarcoma.
5. ovarian cancer, testicular cancer, bladder cancer, . Wilms cancer, prostate cancer, thyroid cancer, neuroblastoma cancer, esophageal cancer, stomach cancer, liver cancer, cervical cancer and head and neck cancer. Multiple myeloma, pancreatic cancer, endometrial cancer and brain tumors can also be applied.
Doxorubicin Hydrochloride COA:
Orange-red or red crystalline powder; No visible
evidence of contamination by foreign matter.
|Identification A||IR spectrum corresponds to the IR spectrum of the reference standard||Confirm|
The retention time of the doxorubicin peak in the chromatogram of the Assay preparation corresponds to that in the chromatogram of the Standard preparation, as obtained in the Assay.
|Solubility||Soluble in water and methanol; slightly soluble in ethanol; practically insoluble in acetone.||Conforms|
|Acetone +Ethanol||≤ 2.5%||0.60%|
|methanol||≤ 0.3%||Not detected|
|Dichloromethane||≤ 0.06%||Not detected|
|pH||4.0 to 5.5||5.1|
|Water Content||≤ 4.0%||0.8%|
|Impurity A (Doxorubicinone)||≤ 0.5%||0.1%|
|Any Other unknown Impurity||≤ 0.1%||0.07%|
|Total unknown Impurities||≤ 0.3%||0.2%|
|Total Impurities||≤ 1.0%||0.9%|
|Conclusion||It complies to reference standard
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