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S4 /Andarine/ Acetamidoxolutamide 401900-40-1 Cutting Excess Body Fat and Bulking
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S4 (Andarine) or Acetamidoxolutamide, is a SARM (Selective Androgen Receptor Modulator). S4 is said to be the most potent SARM which helps sustain lean muscle mass while stimulating fat elimination at the same time. Today, we’ll take a closer look on everything there is to know about S4.
What is S4?
To start, let’s describe what a SARM does. There are three type of chemicals that act on the androgen receptor (AR). One is the an AR antagonist, which is a chemical that binds to the receptor to prevent it from activating. The second is an AR agonist, which binds to the receptor and detaches, then binds again, over and over. An example of an AR agonist is testosterone, each time the AR is bonded with testosterone, a signal is sent out to activate a particular set of genes. The more testosterone that is in the system, the more AR binding will occur. The third is an AR modulator, or basically a molecule that attaches to an AR and changes its structure to react however it wants.
How S4 Works
A SARM such as S-4 is a good example. S-4 attaches to the AR and sticks to it; each time the AR interacts with testosterone, S-4 forces it to produce genes that exclusively benefit muscle and bone growth. In other words, S4 is a form of SARM that attaches to the androgen receptor (AR) the same with regular androgens, the only variation is that S4 generates selective anabolic activity.
S4 is a SARM with utmost androgenic effects as it around 33% of the strength of testosterone when attaching to AR. S-4 also increases the amount of muscle mass produced by desensitizing the AR to the individual’s natural testosterone to influence a stronger effect.
S-4 is by far the most versatile SARM ever created. Not only is it the first SARM approved for a stage 2 research study, it has become the most analyzed and investigated SARM so far. After the discovery of its anabolic potential, the primary purpose of S-4 aimed to develop an alternative treatment to age-related muscle wasting, osteoporosis, and similar symptoms of hypogonadism, or end-stage renal disease.
Aside from preserving lean body mass, S4 can also help improve it. From a stage 1 study, S-4 has provided evidence of a 3.3 lbs increase in less than 90 days with no increases exercise or change in daily diet. An unintended side effect (or benefit if you will) is the decrease in body fat.
Recommended dose for cutting is 50 mg for 6-8 weeks. You should use it every day then take 2 days off for the duration. Taking S4 daily for the length of the cycle can lead to changes in eyesight.
Uses of Andarine
Andarine’s properties are very alike with steroids Anavar and Winstrol, the only difference is that S4 can better provide lean muscle gains. In fact, there have been many cases of bodybuilders gaining up to 3 pounds of lean muscle while on a caloric deficit! S4 displays the same binding resemblance to AR, hence presenting similar fat burning effects.
It also improves vascularity for that “aesthetic” chiseled look with minimal to no water retention. Unlike steroids, it won’t affect your joints but reinforce muscle mass and power instead. You can also say goodbye to painful pumps.
Recommended Dosage: 50 mg for 6-8 weeks.
*Take 2 days off when taking S4 (repeat the cycle after the 2 day break) to avoid vision side effects.
Use S4 with a more anabolic SARM such as Ostarine for better recomp results as you’re aiming to gain muscle while losing fat.
Recommended intake is 50-75 mg for 4 to 8 weeks.
S-4 isn’t the sarm that comes to mind when we think “BULKING”, but it’s properties in muscle gain shouldn’t be overlooked. During the holiday season, many people take advantage of the excess food and snacks available and jump on some well known bulking SARMs such as LGD 4033 or RAD 140.