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Palonosetron Hydrochloride CAS 135729-62-3 Nausea and Vomiting drug

Good quality Anti Aging Drugs for sales
Good quality Anti Aging Drugs for sales
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Palonosetron Hydrochloride CAS 135729-62-3 Nausea and Vomiting drug

China Palonosetron Hydrochloride CAS 135729-62-3 Nausea and Vomiting drug supplier
Palonosetron Hydrochloride CAS 135729-62-3 Nausea and Vomiting drug supplier Palonosetron Hydrochloride CAS 135729-62-3 Nausea and Vomiting drug supplier

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Product Details:

Place of Origin: China
Brand Name: Jusheng Brand
Certification: ISO, 9001, USP
Model Number: 135729-62-3

Payment & Shipping Terms:

Minimum Order Quantity: 10grams
Price: Discount is possible if your order is big enough
Packaging Details: 10g, 20g, 50g , 100g, 500g. 1kg, 10kg
Delivery Time: within 2 working days
Payment Terms: T/T in advance, Money Gram, Western Union, Bank Transfer.
Supply Ability: 1000kg/month
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Detailed Product Description
CAS: 4839-46-7 Apparence: Almost White Crystalline Powder
Purity: 99% Stock: Enough Stock
Grade: Pharma Grade

Palonosetron Hydrochloride CAS 135729-62-3 Nausea and Vomiting drug

 

Quick detail


Product Name: Palonosetron Hydrochloride
Synonyms: (3aS)-2-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-2,3,3a,4,5,6-hexahydro-1H-benz[de]isoquinolin-1-one monohydrochloride;(3aS)-2-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-2,3,3a,4,5,6-hexahydro-1H-benz[de]isoquinolin-1-one Hydrochloride;Aloxi;Onicit;RS-25259-197;(S,S)-Palonosetron Hydrochloride;(S,S)-Palonosetron HCl;(3aS)-2-[(S)-1-Azabicyclo[2.2.2]oct-3-yl]-2,3,3a,4,5,6-hexahydro-1-oxo-1H-benz[de]isoquinoline hydrochloride
CAS: 135729-62-3
MF: C19H25ClN2O
MW: 332.87
EINECS: 680-630-6
Product Categories: Selective 5-HT3 Receptor Antagonist;Chiral Reagents;-;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals

 

 

Description


Palonosetron hydrochloride is a drug to inhibit nausea and vomiting, which is a new type highly selective, high-affinity 5-HT3 receptor antagonist that can block the vomiting reflex center peripheral neurons presynaptic 5-HT. Receptor excitement directly affects the central nervous system in 5-HT. Impulse receptor excitement generated by the role of vagal afferent nerve after area, blocking the vagus nerve endings in the gut, preventing signals to 5-HT. Receptor trigger zone can reduce the incidence of nausea and vomiting. Central clinically for the treatment of acute severe emetogenic chemotherapy induced delayed nausea and vomiting. Because of its high curative effect, little side effect, long half-life (about 40 h), small dosage, and so on, it has attracted much attention.

 

Uses

 


  • Uses Serotonin 5-HT3 receptor antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). Antiemetic.
  • Uses Palonosetron HCl is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting
  • Uses specifically inhibits cells of the adrenal cortex and their production of hormones for adrenocortical tumor therapy, causes CNS damage, but no bone marrow depression.
  • Definition ChEBI: A hydrochloride obtained by combining palonosetron with one molar equivalent of hydrogen chloride; an antiemetic used in combination with netupitant (under the trade name Akynzeo) to treat nausea and vomiting in patients undergoing cancer chemotherapy.
  • Uses Palonosetron is a potent, selective antagonist of the serotonin (5-HT) receptor 5-HT3 (pKi = 10.4 in rat cortex) that minimally effects a wide range of other neuronal receptors. It is orally bioavailable and potently inhibits emesis induced by chemotherapeutic drugs, like cisplatin , but not by apomorphine , which acts by dopamine receptor antagonism. Palonosetron is remarkable for its long duration of action, related to its high receptor-binding affinity and long half-life. It is effective in managing chemotherapy-induced nausea and vomiting.[Cayman Chemical]

 

 

Palonosetron Hydrochloride CAS 135729-62-3 Nausea and Vomiting drug

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