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|CAS:||505-66-8||Apparence:||Almost White Crystalline Powder|
|Purity:||99%||Usage:||Fasudil Hydrochloride Intermediate|
|Stock:||Enough Stock||Packing:||As Your Requirement|
Parmaceutical Intermediate Homopipera Fasudil Hydrochloride CAS 505-66-8
Synonyms:1H-1,4-Diazepine, hexahydro-;hexahydro-1h-4-diazepine;Trimethyleneethylenediamine;HEXAHYDRO-1,4-DIAZEPINE;HEXAHYDRO-1H-1,4-DIAZEPINE;HOMOPIPERAZINE;HPRZ;AKOS BBS-00004278
Product Categories:Piperaizine;Pharmaceutical intermediate;chemical additive;Building Blocks;C4 to C8;Chemical Synthesis;Heterocyclic Building Blocks;Piperazines
Melting point: 38-40 °C(lit.)
Boiling point: 169 °C(lit.)
Appearance: White ppowders
Homopiperazine is a nitrogen-containing seven-membered ring hetero-atomic compound and is an important pharmaceutical intermediate. The majority of its derivatives has strong biological activity and medicinal value and can be used for synthesizing homopiperazine hydrochloride, cyclizine, carbamazepine, chlorcyclizine and other drugs. Western medicine often takes homopiperazine as raw material for the modified quinoline and isoquinoline derivatives, quinolone derivative, thiazolidine carboxylic acid amide derivatives and other drugs, and for the synthesis of pyridazine, nitroxyl-containing benzylamine derivatives, water-soluble azole and other drugs which has good efficacy for the treatment of cardiovascular disease, interstitial plasma cell pneumonia especially for AIDS patients with Pneumocystis pneumonia, asthma, central nervous system disorders including depression and anxiety disorders. For example, 1-(5-isoquinoline-sulfonyl) homopiperazine hydrochloride is effective in the treatment of symptoms such as chronic angina disease, vitiligo, depression, anxiety, cerebral vasospasm and cerebral vasospasm caused cerebral ischemia and other symptoms.
Homopiperazine Chemical Properties
|Melting point||38-40 °C(lit.)|
|Boiling point||169 °C(lit.)|
|refractive index||1.4378 (estimate)|
|color||White to light yellow|
|Water Solubility||Soluble in water.|
|Sensitive||Air Sensitive & Hygroscopic|
It can be used as organic and pharmaceutical synthesis intermediates, for example, being applied to the synthesis of fasudil hydrochloride.
Homopiperazine acts as a corrosion inhibitor for iron. It has also been used in the preparation of potent H3 receptor antagonists for use as treatments for neurodegenerative conditions such as Alzheimer disease.