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|Apparence:||White Crystalline Powder||Purity:||99%|
|Whatapp:||+86 18871490254||Tel.::||+0086 027 59599243|
Promethazine HCL Uses Dosage Raw Material Drug Drug CAS 58-33-3 Neuroleptic Medical
|Product Name:||Promethazine hydrochloride|
|Synonyms:||10-(2-dimethylamino-1-propyl)phenothiazine hydrochloride;PROMETHAZINE HCL;PROMETHAZINE HYDROCHLORIDE;PHENERGAN;10-(2-(dimethylamino)propyl)phenothiazinemonohydrochloride;10-(2-(dimethylamino)propyl)-phenothiazinmonohydrochloride;10-(2-dimethylaminopropyl)phenothiazinehydrochloride;10-(3-dimethylaminoisopropyl)phenothiazinehydrochloride|
|Product Categories:||Active Pharmaceutical Ingredients;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;Histamine receptor;API;COLACE;Inhibitors|
Promethazine is a neuroleptic medication and first-generation antihistamine of the phenothiazine family. The drug has strong sedative and weak antipsychotic effects. It also reduces motion sickness and has antiemetic (Histamine H1 receptors but it does not block the production of histamine) and anticholinergic properties. In some countries it is prescribed for insomnia when benzodiazepines are contraindicated.
Promethazine has a variety of medical uses, including:
As a sedative
For preoperative sedation and to counteract postnarcotic nausea
To reduce nervousness, restlessness and agitation caused by psychiatric conditions (used for this purpose mainly in Europe)
As antiallergic medication to combat hay fever (allergic rhinitis), etc., or to treat allergic reactions, alone or in combination with oral decongestants such as pseudoephedrine
As an adjunct treatment for anaphylactoid conditions (IM/IV route preferred)
Together with codeine or dextromethorphan against cough
As a motion sickness or seasickness remedy when used with ephedrine or pseudoephedrine
To combat moderate to severe morning sickness and hyperemesis gravidarum: In the UK, promethazine is drug of first choice, being preferred as an older drug with which there is a greater experience of use in pregnancy (second in line being metoclopramide or prochlorperazine).
Previously, it was used as an antipsychotic,although it is generally not administered for this purpose now; promethazine has only approximately 1/10 of the antipsychotic strength of chlorpromazine.
Treatment for migraines; however, other similar medications, like Compazine, have been shown to have a more favorable treatment profile, and are used almost exclusively over promethazine.
|Test Items||Specification||Test Results|
|Description||White crystalline powder||White crystalline powder|
|Identification||IR , UV conform||Conform|
|Loss on drying||≤0.5ml||0.21ml|
|Residue on ignition||Not more than 0.2%||0.06ml|
|Iron||Not more than 0.005%||0.0018%|
|Heavy metals||Not more than 0.001%||0.0006%|
|Related substances||Total: Not more than 1.0%
Individual: Not more than 0.5%
|E-isomer||Not more than 0.3%||0.19%|
|Organic volatile impurities||Conforms||Conforms|
|Conclusion||Conform with USP30|