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|Purity:||99%||Other Name:||Akt Inhibitor V Triciribine, API-2 Akt/PKB|
|Function:||Cancer Cure Drug||Stock:||Enough Stock|
Akt Inhibitor V Triciribine CAS 35943-35-2 API-2 Akt/PKB Signaling Cancer Cure Drugs
Product name : Triciribine
Description : Selective, potent inhibitor of Akt activation
Alternative names : API 2: NSC 154020: TCN
Biological description: Cell-permeable tricyclic nucleoside that inhibits the phosphorylation, activation and signalling of Akt. Selective over PKC, PKA, SGK and p38 pathways. Induces cell growth arrest and apoptosis in vitro.
Purity: > 98%
A cell-permeable and reversible tricyclic nucleoside that selectively inhibits the cellular phosphorylation/activation of Akt1/2/3. It does not inhibit known upstream activators of Akt, i.e. PI3K or PDK. Exhibits little effect towards cellular signaling pathways mediated by PKC, PKA, SGK, Stat3, p38, ERK1/2, or JNK. Shown to preferentially induce apoptosis and growth arrest in cancer cells with aberrant Akt activity both in vitro (≥ 60% in cell proliferation at 20 µM) and in vivo (≥ 80% inhibition in tumor growth in mice at 1 mg/kg/day, i.p.). Also available in InSolution™ format.
|Boiling Point:||718.5ºC at 760mmHg|
Akt Inhibitor V, Triciribine, CAS 35943-35-2, is a cell-permeable, selective, reversible inhibitor of the cellular phosphorylation/activation of Akt1/2/3.
Signal Transduction Protein Phosphorylation Ser / Thr Kinases PKB / AKT Biochemicals Chemical Type Biochemicals Biochemicals Chemical Type Nucleoside Biochemicals Pharmacology Enzymes Kinase Akt Inhibitors Biochemicals Pharmacology Signaling Signal transduction PI3K/Akt signaling Akt Inhibitors Biochemicals Research Area Cancer Signal transduction PI3K/Akt signaling Akt Inhibitors