|Place of Origin:||China|
|Brand Name:||Senwayer Brand|
|Certification:||ISO, 9001, USP|
|Minimum Order Quantity:||10grams|
|Price:||Discount is possible if your order is big enough|
|Packaging Details:||10g, 20g, 50g , 100g, 500g. 1kg, 10kg|
|Delivery Time:||within 2 working days|
|Payment Terms:||T/T in advance, Money Gram, Western Union, Bank Transfer.|
|Stock:||Enough Stock||Packing:||As Your Requirement|
|CAS:||122320-73-4||Apparence:||Almost White Crystalline Powder|
|Purity:||99%||Usage:||Antidiabetic Raw Powders|
api raw material,
pharmaceutical raw chemical
Rosiglitazone Maleate CAS 122320-73-4 Maleate Pharma Antidiabetic Raw Powders
Product name: Rosiglitazone
Synonyms: 5-(4-[2-(METHYL-PYRIDIN-2-YL-AMINO)-ETHOXY]-BENZYL)-THIAZOLIDINE-2,4-DIONE;5-[[4-[2-(methyl-2-pyridinylamino)ethoxy]-phenyl]methyl]-2,4-thiazolidine-dione;AVANDIA;ROSIGLITAZONE;ROSIGLITAZONE HCL;Rosiglitazone free base;Rosiglitazone and its intermediates;ROSIGLITAZONE 99%
Key Word: Rosiglitazone, Rosiglitazone Hcl, Rosiglitazone base, AVANDIA,
Rosiglitazone (trade name Avandia) is an antidiabetic drug in the thiazolidinedione class. It works as an insulin sensitizer, by binding to the PPAR in fat cells and making the cells more responsive to insulin. It is marketed by the pharmaceutical company GlaxoSmithKline (GSK) as a stand-alone drug or for use in combination with metformin or with glimepiride.
Rosiglitazone was approved by the US FDA in 1999 and by the EMEA in 2000; the EMEA however required two postmarketing studies on longterm adverse effects, one for chronic heart failure and the other for cardiovascular effects. The drug was approved for glycemic control in people with type 2 diabetes, as measured by glycosylated haemoglobin A1c (HbA1c) as a surrogate endpoint, similar to that of other oral antidiabetic drugs. The controversy over adverse effects has dramatically reduced the use of rosiglitazone.
|Appearance:||White to off-white crystalline powder|
|Boiling Point:||585ºC at 760mmHg|
|Vapor Pressure:||1.14E-13mmHg at 25°C|
Insulin sensitizer; binds to peroxisome proliferator activated receptor gamma (PPAR- γ)
Thiazole alkanes antidiabetic drug
Rosiglitazone was thought to be able to benefit patients with Alzheimer's disease who do not express the ApoE4 allele, but the phase III trial designed to test this showed that rosiglitazone was ineffective in all patients, including ApoE4-negative patients.
Rosiglitazone may also treat mild to moderate ulcerative colitis, due to its anti-inflammatory properties as a PPAR ligand.
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