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CAS 50-23-7 Hydrocortisone Powder

Basic Information
Place of Origin: China
Brand Name: Senwayer Brand
Certification: ISO, 9001, USP
Model Number: 50-23-7
Minimum Order Quantity: 10grams
Price: Discount is possible if your order is big enough
Packaging Details: 10g, 20g, 50g , 100g, 500g. 1kg, 10kg
Delivery Time: within 2 working days
Payment Terms: T/T in advance, Money Gram, Western Union, Bank Transfer.
Supply Ability: 1000kg/month
Detail Information
CAS: 50-23-7 Alias: Hydrocortisone , Beta-Hydrocortisone
Apparence: Almost White Powder Purity: 99%
Usage: For Ulcerative Colitis And Asthma Sepsis Grade: Pharma Grade
High Light:

anti inflammatory medications

,

anti histaminic drugs


Product Description

Hydrocortisone CAS 50-23-7 Glucocorticoids For Ulcerative Colitis and Asthma Sepsis
 
Quick detail


Name: Hydrocortisone
CAS No.: 50-23-7
Formula: C21H30O5
Molecular Weight: 362.46
EINECS: 200-020-1
Density: 1.28 g/cm3
Melting Point 211-214 °C(lit.)
Boiling Point 566.4 °C at 760 mmHg
Flash Point: 310.4 °C
Solubility: water: 100 mg/mL
Appearance: crystalline white powder

 
Introduction of Hydrocortisone


Hydrocortisone is one kind of crystalline white powder.
The IUPAC Name of this chemical is (8S,9S,10R,11S,13S,14S,17R)-11,17-Dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one.
 
In addition, the Classification Code of this chemical is Anti-Inflammatory Agents; Drug / Therapeutic Agent; Glucocorticoid; Mutation data; Reproductive Effect. Hydrocortisone is very slightly soluble in water and sparingly soluble in alcohol.
 
Uses of Hydrocortisone


Hydrocortisone (CAS NO.50-23-7) is used to treat a variety of different illnesses. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.
 
Toxicity of Hydrocortisone


Organism Test Type Route Reported Dose (Normalized Dose) Effect
man TDLo oral 400mg/kg/10D- (400mg/kg) BEHAVIORAL: CHANGES IN PSYCHOPHYSIOLOGICAL TESTS
mouse LD50 subcutaneous > 500mg/kg (500mg/kg)  
rat LD50 intraperitoneal 150mg/kg (150mg/kg)  
rat LD50 subcutaneous 449mg/kg (449mg/kg)  

 
 
Hydrocortisone dosing information


  • Usual Adult Dose for Adrenocortical Insufficiency:

Acute Adrenal Crisis:
100 mg IV followed by IV infusion of 200 mg over 24 hours OR 50 mg IV every 6 hours; then 100 mg IV the following day
Management of Primary Adrenal Insufficiency (PAI):
15 mg to 25 mg orally in 2 or 3 divided doses per day
-Highest dose should be given in the morning, then 2 hours after lunch (2-dose/day regimen) or at lunch and afternoon (3-dose/day regimen)
Prevention of Acute Adrenal Crisis:
Adjust dose according to severity of illness or magnitude of stressor

  • Usual Adult Dose for Sepsis:

200 mg per day by continuous IV infusion
Recommendations from the International Guidelines for Management of Severe Sepsis and Septic Shock 2016:
-IV hydrocortisone should not be used if adequate fluid resuscitation and vasopressor therapy are able to restore hemodynamic stability
-Steroids should not be used in septic patients to prevent septic shock as there is a lack of evidence to support this
-Continuous infusion is recommended over repetitive bolus injections as repetitive boluses have been shown to significantly increase blood glucose
-Taper hydrocortisone treatment when vasopressors no longer required
Use: For the treatment of septic shock when adequate fluid resuscitation and vasopressor therapy are not able to restore hemodynamic stability.

  • Usual Adult Dose for Asthma:

100 mg IV every 8 hours during surgical period; dose should be rapidly reduced within 24 hours after surgery
Use: To reduce risks of complications during and after surgery in patients with asthma.

  • Usual Adult Dose for Ulcerative Colitis:

100 mg rectally (retention enema) nightly for 21 days or until both clinical and protological remission occurs
-Difficult cases may require 2 or 3 months of treatment
Use: As adjunctive therapy in the treatment of ulcerative colitis, especially distal forms.

 

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